INDUCTION OF COLON ADENOCARCINOMAS BY 1,2-DIMETHYLHYDRAZINE IN (C3H*MSM) F1 MICE
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چکیده
منابع مشابه
Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine.
Thirty-four CF1 mice were given weekly s.c. injections of 20 mg of 1,2-dimethylhydrazine hydrochloride per kg; this treatment induced colonie carcinomas in more than 90% of the animals after 186 days. The earliest change was found to be a widening of the proliferative compartment within the colonie crypts; at a later stage, there was an increase of the tritiated thymidine-labeling index from 9....
متن کاملGenetics of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine.
Genetic analysis of colon tumor induction by symmetrical 1,2-dimethylhydrazine (DMH) was undertaken in F1, F2, and reciprocal backcross hybrids derived from a cross between two inbred mouse strains, the 100% susceptible ICR/Ha and completely resistant C57BL/Ha. Mice, 12 to 14 weeks old, received 22 successive weekly s.c. injections of 0.35% aqueous solution of DMH buffered to pH 6.5. A dose of ...
متن کاملChemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds.
Organosulfur compounds (OSCs) present in garlic and onion oil have been shown to inhibit chemical carcinogenesis. In this study, we compared the chemopreventive efficacy of five lipid- and four water-soluble OSCs using the murine nuclear aberration assay. Administration of diallyl sulfide and S-allyl cysteine p.o. at a dose of 200 mg/kg 3 h prior to i.p. 1,2-dimethylhydrazine (DMH) injection (2...
متن کاملChemoprevention of 1,2-Dimethylhydrazine-induced Colon Cancer in Mice by Naturally Occurring Organosulfur Compounds1
Organosulfur compounds (OSCs) present in garlic and onion oil have been shown to inhibit chemical carcinogenesis. In this study, we compared the chemopreventive efficacy of five lipidand four water-soluble OSCs using the murine nuclear aberration assay. Administration of diallyl sulfide and 5-allyl cysteine p.o. at a dose of 200 mg/kg 3 h prior to i.p. 1,2-dimethylhydrazine (DMII) injection (20...
متن کاملEffect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon.
PURPOSE To determine the effect of probiotics on the development of chemically induced (1, 2-dimethylhydrazine) colonic preneoplastic lesions, in mice. METHODS The animals were divided into five groups. The control group was injected with carcinogen alone and the other groups also received probiotics (1- Lactobacillus delbrueckii UFV-H2b20; 2- Bifidobacterium animalis var. lactis Bb12; 3- L. ...
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ژورنال
عنوان ژورنال: Journal of Toxicologic Pathology
سال: 1994
ISSN: 0914-9198,1881-915X
DOI: 10.1293/tox.7.461